Haiti had its latest devastation with the earthquake they suffered two days ago. After being hit by four hurricanes in 2008 and 100s of years of US and French occupation/meddling, the earthquake was very devastating.
With at least three million people homeless, and likely over 100,000 people dead, it would be an understatement to say that things are dire there. Bikes Not Bombs and WBUR have sites you can go to listing organizations that can help. Locally, Partners in Health setup a page with news and ways for people to donate. The Red Cross has setup a way to make a $10 donation by texting "Haiti" to 90999.
With 2.8 million homes foreclosed on in 2009 (higher than in 2008) and more bad economic news to come, it can be tough to find the money to give, but if you can, please do.
UPDATE: Just found out that my employer has a part to play in the Red Cross' 90999 text message donation program. No company on the message path charges anything, so 100% of what you give goes to the Red Cross. Not an endorsement, just a clarification.